In 1995, super soldier Alexei Shostakov and Black Widow Melina Vostokoff work as Russian undercover agents, posing as a family in Ohio with Natasha Romanoff and Yelena Belova as their daughters. They steal S.H.I.E.L.D. intel and escape to Cuba where their boss, General Dreykov, has Romanoff and Belova taken to the Red Room for training. In the following decades, Shostakov is imprisoned in Russia while Romanoff and Belova become successful, dangerous assassins. Romanoff eventually defects to S.H.I.E.L.D. after helping Clint Barton bomb Dreykov's Budapest office, which apparently kills Dreykov and his young daughter Antonia. In 2016, Romanoff is a fugitive for violating the Sokovia Accords.[b] She escapes from U.S. Secretary of State Thaddeus Ross and flees to a safehouse in Norway supplied by Rick Mason. Meanwhile, Belova kills a rogue former Black Widow but comes in contact with a synthetic gas that neutralizes the Red Room's chemical mind-control agent. Belova sends antidote vials to Romanoff, hoping she and the Avengers can free the other Widows, and goes into hiding. When Romanoff is unknowingly driving with the vials in her car, Red Room agent Taskmaster attacks her. Romanoff escapes from Taskmaster and realizes that the vials came from Budapest. There she finds Belova, who reveals that Dreykov is alive and the Red Room is still active. Black Widows and Taskmaster attack them, but Romanoff and Belova evade them and meet with Mason, who supplies them with a helicopter. Romanoff and Belova break Shostakov out of prison to learn Dreykov's location, and he directs them to Vostokoff, who lives on a farm outside Saint Petersburg. There she is refining the chemical mind control process used on the Widows. Vostokoff alerts Dreykov...